Endocrine Abstracts

Bone turnover decreases markedly following both oral glucose and feeding. The mechanism for this is unclear. The aim of this study was to examine whether insulin itself could be responsible for the effect of feeding. We examined the acute effect of a hyperinsulinemic euglycemic clamp (E) and stepwise hyperinsulinemic hypoglycemic clamp (H) on bone turnover and PTH. Sixteen healthy male volunteers (mean age 22) attended on two occasions at 0800 after an overnight fast. The stud...

Many risk factors predict fractures overall, but other factors may be associated with the incidence of vertebral fractures in particular. We carried out a 10-year prospective study of a population-based group of women, ages 50 to 85 years. At baseline we measured bone mineral density (BMD) and collected fasting blood samples for biochemical measurements including serum calcium, alkaline phosphatase, parathyroid hormone, creatinine, phosphate, albumin and thyroid hormones. Medi...

Background: Hypogonadism in men is associated with osteoporosis and low libido. Serum testosterone in men falls after the age of 40 years; however the benefits of replacement therapy are not established. We conducted a double-blind, placebo-controlled trial to investigate the effect of testosterone transdermal patches on bone turnover, body composition, quality of life (QoL) and well-being in men with borderline hypogonadism.Methods: 38 borderline hypogo...